Function and Biology Details
Reactions catalysed:
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assemblies composition:
Assembly name:
Pol protein (preferred)
PDBe Complex ID:
PDB-CPX-108510 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pol protein
Molecule details ›
Chain: A
Length: 563 amino acids
Theoretical weight: 64.9 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 563 amino acids
Theoretical weight: 64.9 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
- Canonical:
A7YKL0 (Residues: 158-720; Coverage: 56%)
Sequence domains:
Pol protein
Molecule details ›
Chain: B
Length: 443 amino acids
Theoretical weight: 51.73 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 443 amino acids
Theoretical weight: 51.73 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
- Canonical: A7YKL0 (Residues: 158-600; Coverage: 44%)
Sequence domains:
