› 5w60

X-ray diffraction
1.8Å resolution

Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol

Released:
DOI: 10.2210/pdb5w60/pdb
PDB entry 5w60 coloured by chain, front view.
PDB entry 5w60 coloured by chain, side view.
PDB entry 5w60 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ensemble Properties of Bax Determine Its Function.
Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM
Structure 26 1346-1359.e5 (2018)
PMID: 30122452

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170507 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator BAX Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-192; Coverage: 100%)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 43.719Å b: 50.716Å c: 64.413Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.238
Expression system: Escherichia coli

Quick links

Citations

5 review citations

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.
Moldoveanu et al. (2020)
4 more

1 mention without citation

Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae.
Zimmerman et al. (2020)