5wbx

X-ray diffraction
1.9Å resolution

Structural insights into the potency of SK/IK channel positive modulators

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-143961 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Small conductance calcium-activated potassium channel protein 2 Chain: B
Molecule details ›
Chain: B
Length: 95 amino acids
Theoretical weight: 11.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2S1 (Residues: 395-486; Coverage: 16%)
Gene name: KCNN2
Sequence domains: Calmodulin binding domain
Structure domains: Helix Hairpins
Calmodulin-1 Chain: R
Molecule details ›
Chain: R
Length: 146 amino acids
Theoretical weight: 16.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 5-148; Coverage: 97%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER D8 QUEST
Spacegroup: C2
Unit cell:
a: 77.328Å b: 66.091Å c: 65.435Å
α: 90° β: 93.84° γ: 90°
R-values:
R R work R free
0.191 0.188 0.243
Expression system: Escherichia coli