› 5wci

X-ray diffraction
1.78Å resolution

Human MYST histone acetyltransferase 1

Released:
DOI: 10.2210/pdb5wci/pdb
PDB entry 5wci coloured by chain, front view.
PDB entry 5wci coloured by chain, side view.
PDB entry 5wci coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Walker JR, Bountra C, Arrowsmith CH, Edwards AM, Zheng YG, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H7Z6 (Residues: 174-449; Coverage: 60%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains:

Ligands and Environments


Cofactor: Ligand 1VU 1 x 1VU
3 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 1 x CL
Ligand EDO 4 x EDO
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 46.336Å b: 58.729Å c: 120.277Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.218
Expression system: Escherichia coli BL21(DE3)

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