› 5wdh

X-ray diffraction
2.25Å resolution

Motor domain of human kinesin family member C1

Released:
DOI: 10.2210/pdb5wdh/pdb
PDB entry 5wdh coloured by chain, front view.
PDB entry 5wdh coloured by chain, side view.
PDB entry 5wdh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Park HW, Ma Z, Zhu H, Jiang S, Robinson RC, Endow SA
Sci Rep 7 15121 (2017)
PMID: 29123223

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIFC1 Chain: A
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 40.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9BW19 (Residues: 307-663; Coverage: 53%)
Gene names: HSET, KIFC1, KNSL2
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand UNX 6 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4122
Unit cell:
a: 63.713Å b: 63.713Å c: 242.432Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.265
Expression system: Trichoplusia ni

Quick links

Citations

9 citation in other articles

Distinct retrograde microtubule motor sets drive early and late endosome transport.
Villari et al. (2020)
8 more

1 mention without citation

Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Park et al. (2017)