Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Small GTPase
- P-loop containing nucleoside triphosphate hydrolase
- Ras guanine-nucleotide exchange factors catalytic domain
- Ras-like guanine nucleotide exchange factor, N-terminal
- Small GTPase, Ras-type
- Small GTP-binding protein domain
- Ras guanine-nucleotide exchange factor, conserved site
- Ras guanine-nucleotide exchange factor, catalytic domain superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
GTPase HRAS - Son of sevenless homolog 1 complex (preferred)
PDBe Complex ID:
PDB-CPX-133979 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GTPase HRas, N-terminally processed
Molecule details ›
Chains: Q, R
Length: 167 amino acids
Theoretical weight: 18.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 167 amino acids
Theoretical weight: 18.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P01112 (Residues: 1-166; Coverage: 88%)
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Son of sevenless homolog 1
Molecule details ›
Chain: N
Length: 482 amino acids
Theoretical weight: 56.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 482 amino acids
Theoretical weight: 56.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q07889 (Residues: 566-1046; Coverage: 36%)
Sequence domains:
Structure domains:
