› 5wfv

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-171935 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 36.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 320-612; Coverage: 47%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller
Nuclear factor erythroid 2-related factor 2 Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16236 (Residues: 76-84; Coverage: 2%)
Gene names: NFE2L2, NRF2

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 162.919Å b: 69.253Å c: 79.228Å
α: 90° β: 118.5° γ: 90°
R-values:
R R work R free
0.2 0.2 0.227
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Mapping the binding sites of challenging drug targets.
Wakefield et al. (2022)
1 more

7 mentions without citation

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease.
Dayalan Naidu et al. (2020)
6 more