Function and Biology Details
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131029 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-lysine N-methyltransferase EZH2; Polycomb protein SUZ12
Molecule details ›
Chains: A, C
Length: 859 amino acids
Theoretical weight: 99.16 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 859 amino acids
Theoretical weight: 99.16 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q15910 (Residues: 2-746; Coverage: 93%) - Canonical: Q15022 (Residues: 543-695; Coverage: 21%)
Sequence domains:
Polycomb protein EED
Molecule details ›
Chains: B, D
Length: 442 amino acids
Theoretical weight: 50.35 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 442 amino acids
Theoretical weight: 50.35 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: O75530 (Residues: 2-441; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
