5wgd

X-ray diffraction
1.8Å resolution

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-136927 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 261 amino acids
Theoretical weight: 29.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 297-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
(ACE)HKILHKLLQDS(NH2) Chain: E
Molecule details ›
Chain: E
Length: 13 amino acids
Theoretical weight: 1.36 KDa
Source organism: synthetic construct
Expression system: Not provided
(ACE)AILHKLLQDS(NH2) Chain: F
Molecule details ›
Chain: F
Length: 12 amino acids
Theoretical weight: 1.16 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 56.037Å b: 83.831Å c: 58.375Å
α: 90° β: 108.32° γ: 90°
R-values:
R R work R free
0.177 0.176 0.208
Expression systems:
  • Escherichia coli
  • Not provided