PDB 5wki structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

protein homodimerization activity

Biological process:

negative regulation of forebrain neuron differentiation

Cellular component:

HFE-transferrin receptor complex

Sequence domains:

4 more domains

Structure analysis Details

Assembly composition:

hetero tetramer (preferred)

PDBe Complex ID:

PDB-CPX-207227 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (5 distinct):

T-cell surface glycoprotein CD1b Chain: A

Molecule details ›

Chain: A
Length: 300 amino acids
Theoretical weight: 33.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P29016 (Residues: 20-296; Coverage: 88%)

Gene name: CD1B
Sequence domains:

Structure domains:

Beta-2-microglobulin Chain: B

Molecule details ›

Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P61769 (Residues: 21-119; Coverage: 100%)

Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ig-like domain-containing protein; T cell receptor alpha variable 26-1 Chain: D

Molecule details ›

Chain: D
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: A0A087WT03 (Residues: 18-107; Coverage: 98%)
Canonical: Q6P4G7 (Residues: 120-213; Coverage: 36%)

Gene names: TRA@, TRAV26-1
Sequence domains:

Structure domains: Immunoglobulins

PG90 TCR beta chain Chain: E

Molecule details ›

Chain: E
Length: 249 amino acids
Theoretical weight: 27.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Structure domains: Immunoglobulins