5wos

X-ray diffraction
2.45Å resolution

Structural and functional insights into Canarypox Virus CNP058 regulation of apoptosis

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-128968 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator Bcl-2 homolog Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 17.28 KDa
Source organism: Canarypox virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6VZT9 (Residues: 1-143; Coverage: 82%)
Gene name: CNPV058
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 141-166; Coverage: 13%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 73.786Å b: 34.67Å c: 71.726Å
α: 90° β: 114.92° γ: 90°
R-values:
R R work R free
0.214 0.212 0.245
Expression systems:
  • Escherichia coli
  • Not provided