› 5wtd

X-ray diffraction
2.5Å resolution

Structure of human serum transferrin bound ruthenium at N-lobe

Released:
DOI: 10.2210/pdb5wtd/pdb
PDB entry 5wtd coloured by chain, front view.
PDB entry 5wtd coloured by chain, side view.
PDB entry 5wtd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of ruthenium and osmium at non‑iron sites of transferrin accounts for their iron-independent cellular uptake.
Wang M, Wang H, Xu X, Lai TP, Zhou Y, Hao Q, Li H, Sun H
J Inorg Biochem 234 111885 (2022)
PMID: 35690040

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 679 amino acids
Theoretical weight: 75.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 20-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand FE 1 x FE
Ligand MLI 1 x MLI
Ligand RU 1 x RU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 137.113Å b: 157.351Å c: 107.086Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.214

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Citations

1 review citation

The Multifaceted Roles of Bovine Lactoferrin: Molecular Structure, Isolation Methods, Analytical Characteristics, and Biological Properties.
Dyrda-Terniuk et al. (2023)
4 other articles