Function and Biology Details
Reaction catalysed:
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127063 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptotic protease-activating factor 1
Molecule details ›
Chains: A, C, E
Length: 95 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas
Length: 95 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O14727 (Residues: 1-95; Coverage: 8%)
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas
Caspase-9 subunit p35
Molecule details ›
Chains: B, D, F
Length: 151 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas
Length: 151 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P55211 (Residues: 1-128; Coverage: 31%)
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas
