› 5wxs

X-ray diffraction
2.3Å resolution

Crystal structure of uPA in complex with S2444

Released:
DOI: 10.2210/pdb5wxs/pdb
PDB entry 5wxs coloured by chain, front view.
PDB entry 5wxs coloured by chain, side view.
PDB entry 5wxs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jiang L, Huang M

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator chain B Chain: U
Molecule details ›
Chain: U
Length: 253 amino acids
Theoretical weight: 28.44 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00749 (Residues: 179-431; Coverage: 62%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand 7YF 1 x 7YF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: R3
Unit cell:
a: 120.435Å b: 120.435Å c: 42.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.185 0.266
Expression system: Komagataella pastoris

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