› 5x0t

X-ray diffraction
2.5Å resolution

Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8

Released:
DOI: 10.2210/pdb5x0t/pdb
PDB entry 5x0t coloured by chain, front view.
PDB entry 5x0t coloured by chain, side view.
PDB entry 5x0t coloured by chain, top view.
Source organisms:
Entry authors: Lin P, Zhang M-Y, Ye S, Chen X, Yu X-L, Zhang R-G, Zhu P, Chen Z-N

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211114 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
6H8 Fab fragment heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 241 amino acids
Theoretical weight: 26.33 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
6H8 Fab fragment light chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 234 amino acids
Theoretical weight: 25.91 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Basigin Chains: E, F
Molecule details ›
Chains: E, F
Length: 89 amino acids
Theoretical weight: 9.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35613 (Residues: 138-217; Coverage: 22%)
Gene names: BSG, UNQ6505/PRO21383

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 46.986Å b: 83.486Å c: 130.193Å
α: 90° β: 92.92° γ: 90°
R-values:
R R work R free
0.248 0.246 0.3
Expression systems:
  • Mus musculus
  • Escherichia coli

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