› 5x16

X-ray diffraction
1.97Å resolution

Sirt6 apo structure

Released:
DOI: 10.2210/pdb5x16/pdb
PDB entry 5x16 coloured by chain, front view.
PDB entry 5x16 coloured by chain, side view.
PDB entry 5x16 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang J, Huang Z, Song K

Function and Biology Details

Reaction catalysed: 
(1a) [protein]-N(6)-acetyl-L-lysine + NAD(+) = [protein]-N(6)-(1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl)-L-lysine + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase sirtuin-6 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N6T7 (Residues: 3-318; Coverage: 89%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand AR6 1 x AR6
Ligand ZN 1 x ZN
Ligand TBU 2 x TBU
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 42.565Å b: 68.138Å c: 117.314Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.232
Expression system: Homo sapiens

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