› 5x8m

X-ray diffraction
2.66Å resolution

PD-L1 in complex with durvalumab

Released:
DOI: 10.2210/pdb5x8m/pdb
PDB entry 5x8m coloured by chain, front view.
PDB entry 5x8m coloured by chain, side view.
PDB entry 5x8m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab.
Lee HT, Lee JY, Lim H, Lee SH, Moon YJ, Pyo HJ, Ryu SE, Shin W, Heo YS
Sci Rep 7 5532 (2017)
PMID: 28717238

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212802 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Programmed cell death 1 ligand 1 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-134; Coverage: 43%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
durvalumab heavy chain Chain: B
Molecule details ›
Chain: B
Length: 235 amino acids
Theoretical weight: 25.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
Structure domains: Immunoglobulins
durvalumab light chain Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 23.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 39.95Å b: 97.395Å c: 153.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.219
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

39 review citations

First line Immunotherapy for Non-Small Cell Lung Cancer.
Nasser et al. (2020)
38 more

14 mentions without citation

Biotherapeutic Antibodies for the Treatment of Head and Neck Cancer: Current Approaches and Future Considerations of Photothermal Therapies.
Al Qaraghuli MM. (2020)
13 more