› 5xaw

X-ray diffraction
2.1Å resolution

Parallel homodimer structures of voltage-gated sodium channel beta4 for cell-cell adhesion

Released:
DOI: 10.2210/pdb5xaw/pdb
PDB entry 5xaw coloured by chain, front view.
PDB entry 5xaw coloured by chain, side view.
PDB entry 5xaw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.
Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S
J Biol Chem 292 13428-13440 (2017)
PMID: 28655765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184892 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q8IWT1 (Residues: 30-152; Coverage: 62%)
Gene name: SCN4B
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand P33 2 x P33
Ligand PG4 3 x PG4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P32
Unit cell:
a: 57.079Å b: 57.079Å c: 72.024Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.204 0.264
Expression system: Escherichia coli K-12

Quick links

Citations

3 review citations

Voltage-Gated Sodium Channel β Subunits and Their Related Diseases.
Bouza et al. (2018)
2 more

2 mentions without citation

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels.
Salvage et al. (2020)
1 more