› 5xfn

X-ray diffraction
1.9Å resolution

Structure of the N-terminal domains of PHF1

Released:
DOI: 10.2210/pdb5xfn/pdb
PDB entry 5xfn coloured by chain, front view.
PDB entry 5xfn coloured by chain, side view.
PDB entry 5xfn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Polycomb-like proteins link the PRC2 complex to CpG islands.
Li H, Liefke R, Jiang J, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z
Nature 549 287-291 (2017)
PMID: 28869966

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PHD finger protein 1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43189 (Residues: 25-340; Coverage: 56%)
Gene names: PCL1, PHF1
Sequence domains:
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 40.025Å b: 62Å c: 135.368Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

64 review citations

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.
Laugesen et al. (2019)
63 more

2 mentions without citation

Polycomb-like proteins link the PRC2 complex to CpG islands.
Li et al. (2017)
1 more