› 5xp7

X-ray diffraction
2.01Å resolution

C-Src in complex with ATP-CHCl

Released:
DOI: 10.2210/pdb5xp7/pdb
PDB entry 5xp7 coloured by chain, front view.
PDB entry 5xp7 coloured by chain, side view.
PDB entry 5xp7 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.
Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C
J Am Chem Soc 139 7701-7704 (2017)
PMID: 28535041

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 8C6 2 x 8C6
Ligand MG 2 x MG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 42.276Å b: 63.978Å c: 74.003Å
α: 101.03° β: 89.83° γ: 90.6°
R-values:
R R work R free
0.169 0.168 0.198
Expression system: Escherichia coli K-12

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Citations

1 review citation

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors.
Dai et al. (2019)
6 other articles

2 mentions without citation

Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses.
He et al. (2022)
1 more