› 5y2t

X-ray diffraction
1.7Å resolution

Structure of PPARgamma ligand binding domain - lobeglitazone complex

Released:
DOI: 10.2210/pdb5y2t/pdb
PDB entry 5y2t coloured by chain, front view.
PDB entry 5y2t coloured by chain, side view.
PDB entry 5y2t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of PPARĪ³ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs.
Lee MA, Tan L, Yang H, Im YG, Im YJ
Sci Rep 7 16837 (2017)
PMID: 29203903

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 8LX 2 x 8LX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 56.267Å b: 88.485Å c: 57.999Å
α: 90° β: 89.83° γ: 90°
R-values:
R R work R free
0.194 0.192 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond.
Devchand et al. (2018)
3 more

7 mentions without citation

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae.
Salazar et al. (2020)
6 more