› 5y7x

X-ray diffraction
1.7Å resolution

Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist

Released:
DOI: 10.2210/pdb5y7x/pdb
PDB entry 5y7x coloured by chain, front view.
PDB entry 5y7x coloured by chain, side view.
PDB entry 5y7x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kim HL, Chin JW, Cho SJ, Song JY, Yoon HS, Bae JH

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169864 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 171-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

5 bound ligands:
Ligand 8RR 2 x 8RR
Ligand K 1 x K
Ligand CL 2 x CL
Ligand PGO 1 x PGO
Ligand JZR 2 x JZR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 39.766Å b: 93.896Å c: 96.871Å
α: 90° β: 97.4° γ: 90°
R-values:
R R work R free
0.206 0.205 0.23
Expression system: Escherichia coli

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