› 5ya5

X-ray diffraction
1.89Å resolution

CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR

Released:
DOI: 10.2210/pdb5ya5/pdb
PDB entry 5ya5 coloured by chain, front view.
PDB entry 5ya5 coloured by chain, side view.
PDB entry 5ya5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.
Yuan H, Liu Q, Zhang L, Hu S, Chen T, Li H, Chen Y, Xu Y, Lu T
Eur J Med Chem 143 491-502 (2018)
PMID: 29202410

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 319 amino acids
Theoretical weight: 36.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08581 (Residues: 1038-1346; Coverage: 23%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

1 bound ligand:
Ligand 6TD 1 x 6TD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 42.36Å b: 47.34Å c: 158.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies.
Nitulescu et al. (2023)
4 other articles

2 mentions without citation

A novel anti-lung cancer agent inhibits proliferation and epithelial-mesenchymal transition.
Zhao et al. (2022)
1 more