› 5ybf

X-ray diffraction
1.5Å resolution

Crystal structure of the GluA2o LBD in complex with glutamate and HBT1

Released:
DOI: 10.2210/pdb5ybf/pdb
PDB entry 5ybf coloured by chain, front view.
PDB entry 5ybf coloured by chain, side view.
PDB entry 5ybf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H
J Pharmacol Exp Ther 364 377-389 (2018)
PMID: 29298820

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 263 amino acids
Theoretical weight: 29.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42262 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GLUR2, GRIA2, GluA2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand GLU 6 x GLU
Ligand 8SR 3 x 8SR
Ligand ZN 10 x ZN
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 113.596Å b: 162.074Å c: 47.103Å
α: 90° β: 89.99° γ: 90°
R-values:
R R work R free
0.185 0.184 0.208
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: A long and winding road.
Kadriu et al. (2021)
1 more

1 mention without citation

Neuroprotective activity of novel phenanthrene derivative from Grewia tiliaefolia by in vitro and in silico studies.
Rajput et al. (2023)