› 5yde

X-ray diffraction
1.02Å resolution

Crystal structure of a disease-related gene, hCDC73(1-111)

Released:
DOI: 10.2210/pdb5yde/pdb
PDB entry 5yde coloured by chain, front view.
PDB entry 5yde coloured by chain, side view.
PDB entry 5yde coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome.
Sun W, Kuang XL, Liu YP, Tian LF, Yan XX, Xu W
Sci Rep 7 15638 (2017)
PMID: 29142233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180101 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parafibromin Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P1J9 (Residues: 1-111; Coverage: 21%)
Gene names: C1orf28, CDC73, HRPT2
Sequence domains: Paf1 complex subunit CDC73 N-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 38.091Å b: 43.683Å c: 67.626Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.12 0.119 0.139
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective.
Marx et al. (2019)
8 other articles

6 mentions without citation

The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.
Francette et al. (2021)
5 more