› 5ydf

X-ray diffraction
1.4Å resolution

Crystal structure of a disease-related gene, hCDC73(1-100)

Released:
DOI: 10.2210/pdb5ydf/pdb
PDB entry 5ydf coloured by chain, front view.
PDB entry 5ydf coloured by chain, side view.
PDB entry 5ydf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome.
Sun W, Kuang XL, Liu YP, Tian LF, Yan XX, Xu W
Sci Rep 7 15638 (2017)
PMID: 29142233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180101 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parafibromin Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P1J9 (Residues: 1-100; Coverage: 19%)
Gene names: C1orf28, CDC73, HRPT2
Sequence domains: Paf1 complex subunit CDC73 N-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 28.59Å b: 53.504Å c: 65.734Å
α: 90° β: 95.66° γ: 90°
R-values:
R R work R free
0.137 0.135 0.174
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.
Francette et al. (2021)
1 more

1 mention without citation

Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome.
Sun et al. (2017)