› 5ydx

Solution NMR

NMR structure of YAP1-2 WW1 domain with LATS1 PPxY motif complex

Released:
DOI: 10.2210/pdb5ydx/pdb
PDB entry 5ydx coloured by chain, ensemble of 20 models, front view.
PDB entry 5ydx coloured by chain, ensemble of 20 models, side view.
PDB entry 5ydx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.
Verma A, Jing-Song F, Finch-Edmondson ML, Velazquez-Campoy A, Balasegaran S, Sudol M, Sivaraman J
Oncotarget 9 8068-8080 (2018)
PMID: 29487715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional coactivator YAP1 Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.58 KDa
Source organism: Homo sapiens
Expression system: Cloning vector pGEM3_Zf
UniProt:
  • Canonical: P46937 (Residues: 164-218; Coverage: 11%)
Gene names: YAP1, YAP65
Sequence domains: WW domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Cloning vector pGEM3_Zf

Quick links

Citations

2 review citations

Context-dependent roles of YAP/TAZ in stem cell fates and cancer.
LeBlanc et al. (2021)
1 more

2 mentions without citation

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.
Verma et al. (2018)
1 more