5yh2

X-ray diffraction
3.55Å resolution

The structure of DrFam20C1 and hFam20A complex

Released:
Source organisms:
Primary publication:
Structure and evolution of the Fam20 kinases.
Nat Commun 9 1218 (2018)
PMID: 29572475

Function and Biology Details

Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-123078 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pseudokinase FAM20A Chains: A, B
Molecule details ›
Chains: A, B
Length: 467 amino acids
Theoretical weight: 53.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96MK3 (Residues: 63-529; Coverage: 92%)
Gene names: FAM20A, UNQ9388/PRO34279
Sequence domains: Golgi casein kinase, C-terminal, Fam20
FAM20 C-terminal domain-containing protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 560 amino acids
Theoretical weight: 64.51 KDa
Source organism: Danio rerio
Expression system: Trichoplusia ni
UniProt:
  • Canonical: E7FBB8 (Residues: 1-129, 130-450, 451-453, 454-545; Coverage: 100%)
Gene name: fam20ca
Sequence domains: Golgi casein kinase, C-terminal, Fam20

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P41212
Unit cell:
a: 110.059Å b: 110.059Å c: 461.698Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.245 0.298
Expression system: Trichoplusia ni