› 5yp7

X-ray diffraction
1.42Å resolution

p62/SQSTM1 ZZ domain

Released:
DOI: 10.2210/pdb5yp7/pdb
PDB entry 5yp7 coloured by chain, front view.
PDB entry 5yp7 coloured by chain, side view.
PDB entry 5yp7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.
Kwon DH, Park OH, Kim L, Jung YO, Park Y, Jeong H, Hyun J, Kim YK, Song HK
Nat Commun 9 3291 (2018)
PMID: 30120248

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 55 amino acids
Theoretical weight: 5.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13501 (Residues: 126-180; Coverage: 13%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: Zinc finger, ZZ type

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Unit cell:
a: 34.749Å b: 43.345Å c: 54.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.207
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging.
Kumar et al. (2022)
8 more

3 mentions without citation

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.
Kwon et al. (2018)
2 more