5yve

X-ray diffraction
3.4Å resolution

Crystal structure of human P2X3 receptor in complex with the AF-219 negative allosteric modulator

Released:
Source organism: Homo sapiens
Primary publication:
Druggable negative allosteric site of P2X3 receptors.
Proc Natl Acad Sci U S A 115 4939-4944 (2018)
PMID: 29674445

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor 3 Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 40.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P56373 (Residues: 6-364; Coverage: 90%)
Gene name: P2RX3
Sequence domains: ATP P2X receptor
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R32
Unit cell:
a: 119.613Å b: 119.613Å c: 235.691Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.235 0.296
Expression system: Homo sapiens