› 5yxn

X-ray diffraction
2.03Å resolution

A T cell receptor in complex with HLA-A0201 restricted Hepatitis C virus NS3 peptide (KLVALGINAV)

Released:
DOI: 10.2210/pdb5yxn/pdb
PDB entry 5yxn coloured by chain, front view.
PDB entry 5yxn coloured by chain, side view.
PDB entry 5yxn coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Hui F

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-209022 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
T cell receptor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
T cell receptor beta chain Chain: B
Molecule details ›
Chain: B
Length: 241 amino acids
Theoretical weight: 27.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
HLA class I histocompatibility antigen, A alpha chain Chain: C
Molecule details ›
Chain: C
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: D
Molecule details ›
Chain: D
Length: 100 amino acids
Theoretical weight: 11.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 20-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Serine protease/helicase NS3 Chain: I
Molecule details ›
Chain: I
Length: 10 amino acids
Theoretical weight: 998 Da
UniProt:
  • Canonical: P27958 (Residues: 1406-1415; Coverage: 0%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Unit cell:
a: 79.99Å b: 53.65Å c: 224.981Å
α: 90° β: 95.27° γ: 90°
R-values:
R R work R free
0.194 0.193 0.223
Expression system: Escherichia coli

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