› 5yz5

X-ray diffraction
1.8Å resolution

Crystal Structure of Human CRMP-2 with T509D-T514D-S518D-S522D mutations

Released:
DOI: 10.2210/pdb5yz5/pdb
PDB entry 5yz5 coloured by chain, front view.
PDB entry 5yz5 coloured by chain, side view.
PDB entry 5yz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Altering Function of CRMP2 by Phosphorylation.
Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, Nitta R
Cell Struct Funct 43 15-23 (2018)
PMID: 29479005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropyrimidinase-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 525 amino acids
Theoretical weight: 57.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16555 (Residues: 1-525; Coverage: 92%)
Gene names: CRMP2, DPYSL2, ULIP2
Sequence domains: Amidohydrolase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: I4122
Unit cell:
a: 114.117Å b: 114.117Å c: 196.074Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective.
Nouri et al. (2019)
1 more

2 mentions without citation

Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer.
Ryan et al. (2021)
1 more