› 5yzb

X-ray diffraction
2.8Å resolution

Crystal Structure of Human CRMP-2 with S522D-T509D-T514D-S518D mutations crystallized with GSK3b

Released:
DOI: 10.2210/pdb5yzb/pdb
PDB entry 5yzb coloured by chain, front view.
PDB entry 5yzb coloured by chain, side view.
PDB entry 5yzb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Altering Function of CRMP2 by Phosphorylation.
Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, Nitta R
Cell Struct Funct 43 15-23 (2018)
PMID: 29479005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropyrimidinase-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 525 amino acids
Theoretical weight: 57.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16555 (Residues: 1-525; Coverage: 92%)
Gene names: CRMP2, DPYSL2, ULIP2
Sequence domains: Amidohydrolase family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: I4122
Unit cell:
a: 114.34Å b: 114.34Å c: 194.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.266
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective.
Nouri et al. (2019)
1 more