› 5z15

X-ray diffraction
2.9Å resolution

Crystal structure of human TLR8 in complex with CU-CPT9c

Released:
DOI: 10.2210/pdb5z15/pdb
PDB entry 5z15 coloured by chain, front view.
PDB entry 5z15 coloured by chain, side view.
PDB entry 5z15 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tanji H, Ohto U, Shimizu T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192550 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Toll-like receptor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 811 amino acids
Theoretical weight: 92.84 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9NR97 (Residues: 27-827; Coverage: 79%)
Gene names: TLR8, UNQ249/PRO286
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand 7VL 2 x 7VL
Ligand MAN 1 x MAN
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 143.892Å b: 98.747Å c: 139.476Å
α: 90° β: 109.04° γ: 90°
R-values:
R R work R free
0.206 0.202 0.289
Expression system: Drosophila melanogaster

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