5ac7

X-ray diffraction
1.9Å resolution

S. enterica HisA with mutations D7N, D10G, dup13-15

Released:

Function and Biology Details

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-145288 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 27.43 KDa
Source organism: Salmonella enterica
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10372 (Residues: 1-15, 17-245; Coverage: 100%)
Gene names: STM2076, hisA
Sequence domains: Histidine biosynthesis protein
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 61.999Å b: 61.999Å c: 607.094Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.186 0.214
Expression system: Escherichia coli BL21(DE3)