5ac8

X-ray diffraction
1.7Å resolution

S. enterica HisA with mutations D10G, dup13-15, G102A

Released:

Function and Biology Details

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-145288 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 27.44 KDa
Source organism: Salmonella enterica
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10372 (Residues: 1-15, 17-245; Coverage: 100%)
Gene names: STM2076, hisA
Sequence domains: Histidine biosynthesis protein
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6122
Unit cell:
a: 86.415Å b: 86.415Å c: 122.027Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.196 0.209
Expression system: Escherichia coli BL21(DE3)