› 5b79

X-ray diffraction
2.6Å resolution

Crystal structure of DPF2 double PHD finger

Released:
DOI: 10.2210/pdb5b79/pdb
PDB entry 5b79 coloured by chain, front view.
PDB entry 5b79 coloured by chain, side view.
PDB entry 5b79 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.
Xiong X, Panchenko T, Yang S, Zhao S, Yan P, Zhang W, Xie W, Li Y, Zhao Y, Allis CD, Li H
Nat Chem Biol 12 1111-1118 (2016)
PMID: 27775714

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger protein ubi-d4 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92785 (Residues: 270-391; Coverage: 31%)
Gene names: BAF45D, DPF2, REQ, UBID4
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: I422
Unit cell:
a: 106.979Å b: 106.979Å c: 52.592Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.189 0.238
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali et al. (2018)
33 more

5 mentions without citation

Conserved Structure and Evolution of DPF Domain of PHF10-The Specific Subunit of PBAF Chromatin Remodeling Complex.
Chugunov et al. (2021)
4 more