› 5bqd

X-ray diffraction
2.58Å resolution

Crystal Structure of TBX5 (1-239) Dimer

Released:
DOI: 10.2210/pdb5bqd/pdb
PDB entry 5bqd coloured by chain, front view.
PDB entry 5bqd coloured by chain, side view.
PDB entry 5bqd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.
Pradhan L, Gopal S, Li S, Ashur S, Suryanarayanan S, Kasahara H, Nam HJ
Biochemistry 55 1702-10 (2016)
PMID: 26926761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor TBX5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 239 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99593 (Residues: 1-239; Coverage: 46%)
Gene name: TBX5
Sequence domains: T-box
Structure domains: Transcription factor, T-box

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P6122
Unit cell:
a: 81.455Å b: 81.455Å c: 341.022Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.246 0.289
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Targeting GATA4 for cardiac repair.
Välimäki et al. (2020)
2 more

1 mention without citation

Identification of deleterious single nucleotide polymorphism (SNP)s in the human TBX5 gene & prediction of their structural & functional consequences: An in silico approach.
Mahfuz et al. (2021)