Function and Biology Details
Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
tPA-PAI-1 complex (preferred)
PDBe Complex ID:
PDB-CPX-133301 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Plasminogen activator inhibitor 1
Molecule details ›
Chain: I
Length: 379 amino acids
Theoretical weight: 42.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Length: 379 amino acids
Theoretical weight: 42.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P05121 (Residues: 24-402; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Tissue-type plasminogen activator chain B
Molecule details ›
Chain: E
Length: 252 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii CBS 7435
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 252 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii CBS 7435
UniProt:
- Canonical: P00750 (Residues: 311-562; Coverage: 47%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
