› 5c5b

X-ray diffraction
2.9Å resolution

Crystal Structure of Human APPL BAR-PH Heterodimer

Released:
DOI: 10.2210/pdb5c5b/pdb
PDB entry 5c5b coloured by chain, front view.
PDB entry 5c5b coloured by chain, side view.
PDB entry 5c5b coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chen YJ, Chen B

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185516 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DCC-interacting protein 13-alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 375 amino acids
Theoretical weight: 42.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UKG1 (Residues: 5-375; Coverage: 52%)
Gene names: APPL, APPL1, DIP13A, KIAA1428
Sequence domains:
Structure domains:
DCC-interacting protein 13-beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 375 amino acids
Theoretical weight: 42.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NEU8 (Residues: 1-375; Coverage: 57%)
Gene names: APPL2, DIP13B
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 146.924Å b: 88.542Å c: 147.388Å
α: 90° β: 92.65° γ: 90°
R-values:
R R work R free
0.214 0.21 0.268
Expression system: Escherichia coli BL21(DE3)

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