› 5c5s

X-ray diffraction
2.2Å resolution

Crystal Structure of human Myosin 9b RhoGAP domain at 2.2 angstrom

Released:
DOI: 10.2210/pdb5c5s/pdb
PDB entry 5c5s coloured by chain, front view.
PDB entry 5c5s coloured by chain, side view.
PDB entry 5c5s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
Kong R, Yi F, Wen P, Liu J, Chen X, Ren J, Li X, Shang Y, Nie Y, Wu K, Fan D, Zhu L, Feng W, Wu JY
J Clin Invest 125 4407-20 (2015)
PMID: 26529257

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-IXb Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 232 amino acids
Theoretical weight: 26.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13459 (Residues: 1691-1916; Coverage: 11%)
Gene names: MYO9B, MYR5
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 77.084Å b: 84.984Å c: 134.139Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Slit-Robo signaling.
Blockus et al. (2016)
10 more

6 mentions without citation

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
Kong et al. (2015)
5 more