› 5ce1

X-ray diffraction
2.5Å resolution

Crystal Structure of Serine protease Hepsin in complex with Inhibitor

Released:
DOI: 10.2210/pdb5ce1/pdb
PDB entry 5ce1 coloured by chain, front view.
PDB entry 5ce1 coloured by chain, side view.
PDB entry 5ce1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rao KN, Anita RC, Sangeetha R, Anirudha L, Subramnay H

Function and Biology Details

Reaction catalysed: 
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease hepsin catalytic chain Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 40.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05981 (Residues: 46-417; Coverage: 89%)
Gene names: HPN, TMPRSS1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 50K 1 x 50K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 59.583Å b: 47.678Å c: 60.784Å
α: 90° β: 105.3° γ: 90°
R-values:
R R work R free
0.192 0.187 0.282
Expression system: Spodoptera frugiperda

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