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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

X-ray diffraction
3Å resolution
PDB entry 5cox coloured by chain, front view.
PDB entry 5cox coloured by chain, side view.
PDB entry 5cox coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Prostaglandin G/H synthase 2
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Multimeric state: homo dimer
Accessible surface area: 41915.32 Å2
Buried surface area: 8983.32 Å2
Dissociation area: 2,447.13 Å2
Dissociation energy (ΔGdiss): 20.11 kcal/mol
Dissociation entropy (TΔSdiss): 15.3 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170244
Assembly 2
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Assembly Name: Prostaglandin G/H synthase 2
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Multimeric state: homo dimer
Accessible surface area: 41851.14 Å2
Buried surface area: 8968.69 Å2
Dissociation area: 2,422.26 Å2
Dissociation energy (ΔGdiss): 18.92 kcal/mol
Dissociation entropy (TΔSdiss): 15.29 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170244

Macromolecules

Prostaglandin G/H synthase 2
Chains: A, B, C, D
Length: 587 amino acids
Theoretical weight: 67.32 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 18-604; Coverage: 100%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Pfam:
InterPro:
CATH:
SCOP:
Prostaglandin G/H synthase 2 in PDB entry 5cox, assembly 1, front view.
Prostaglandin G/H synthase 2 in PDB entry 5cox, assembly 1, side view.
Prostaglandin G/H synthase 2 in PDB entry 5cox, assembly 1, top view.
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