› 5csv

X-ray diffraction
1.38Å resolution

Crystal Structure of CK2alpha with Compound 6 bound

Released:
DOI: 10.2210/pdb5csv/pdb
PDB entry 5csv coloured by chain, front view.
PDB entry 5csv coloured by chain, side view.
PDB entry 5csv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Specific inhibition of CK2α from an anchor outside the active site.
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M
Chem Sci 7 6839-6845 (2016)
PMID: 28451126

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 39.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68400 (Residues: 2-329; Coverage: 84%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand GAB 1 x GAB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 58.525Å b: 45.433Å c: 63.423Å
α: 90° β: 111.73° γ: 90°
R-values:
R R work R free
0.18 0.18 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2.
Spinello et al. (2021)
2 more

4 mentions without citation

Specific inhibition of CK2α from an anchor outside the active site.
Brear et al. (2016)
3 more