› 5czw

X-ray diffraction
1.6Å resolution

Crystal structure of myroilysin

Released:
DOI: 10.2210/pdb5czw/pdb
PDB entry 5czw coloured by chain, front view.
PDB entry 5czw coloured by chain, side view.
PDB entry 5czw coloured by chain, top view.
Source organism: Myroides profundi
Primary publication:
Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism.
Xu D, Zhou J, Lou X, He J, Ran T, Wang W
J Biol Chem 292 5195-5206 (2017)
PMID: 28188295

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase metallopeptidase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.67 KDa
Source organism: Myroides profundi
Expression system: Escherichia coli
UniProt:
  • Canonical: B5B0E6 (Residues: 35-272; Coverage: 87%)
Gene name: MPR_2201
Sequence domains: Astacin (Peptidase family M12A)

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand MLY 5 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 51.159Å b: 35.134Å c: 64.258Å
α: 90° β: 110.12° γ: 90°
R-values:
R R work R free
0.203 0.201 0.254
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy.
Li et al. (2021)
1 other article

3 mentions without citation

Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12.
Haas et al. (2018)
2 more