› 5dkd

X-ray diffraction
2Å resolution

Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe

Released:
DOI: 10.2210/pdb5dkd/pdb
PDB entry 5dkd coloured by chain, front view.
PDB entry 5dkd coloured by chain, side view.
PDB entry 5dkd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Gerstenberger BS, Fedorov O, Savitsky P, Nunez-Alonso G, Newman JA, Filippakopoulos P, Burgess-Brown N, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Muller S, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription activator BRG1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 14.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51532 (Residues: 1451-1569; Coverage: 7%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand EDO 6 x EDO
Ligand 5BW 2 x 5BW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 45.926Å b: 74.566Å c: 52.626Å
α: 90° β: 109.9° γ: 90°
R-values:
R R work R free
0.269 0.268 0.297
Expression system: Escherichia coli

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