› 5dss

X-ray diffraction
2.8Å resolution

MP-4 contributes to snake venom neutralization by Mucuna pruriens seeds through stimulation of cross-reactive antibodies

Released:
DOI: 10.2210/pdb5dss/pdb
PDB entry 5dss coloured by chain, front view.
PDB entry 5dss coloured by chain, side view.
PDB entry 5dss coloured by chain, top view.
Source organism: Mucuna pruriens
Primary publication:
MP-4 Contributes to Snake Venom Neutralization by Mucuna pruriens Seeds through an Indirect Antibody-mediated Mechanism.
Kumar A, Gupta C, Nair DT, Salunke DM
J Biol Chem 291 11373-84 (2016)
PMID: 26987900

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MP-4 Chain: B
Molecule details ›
Chain: B
Length: 185 amino acids
Theoretical weight: 20.18 KDa
Source organism: Mucuna pruriens
UniProt:
  • Canonical: A0A158RFS0 (Residues: 1-185; Coverage: 100%)
Sequence domains: Trypsin and protease inhibitor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21212
Unit cell:
a: 51Å b: 69.18Å c: 45.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.267 0.284

Quick links

Citations

2 review citations

Antibody Cross-Reactivity in Antivenom Research.
Ledsgaard et al. (2018)
1 more

3 mentions without citation

MP-4 Contributes to Snake Venom Neutralization by Mucuna pruriens Seeds through an Indirect Antibody-mediated Mechanism.
Kumar et al. (2016)
2 more