› 5ea1

X-ray diffraction
2Å resolution

Crystal Structure of SMARCA4 bromodomain in complex with MPD

Released:
DOI: 10.2210/pdb5ea1/pdb
PDB entry 5ea1 coloured by chain, front view.
PDB entry 5ea1 coloured by chain, side view.
PDB entry 5ea1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography.
Lolli G, Caflisch A
ACS Chem Biol 11 800-7 (2016)
PMID: 26942307

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription activator BRG1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 132 amino acids
Theoretical weight: 15.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51532 (Residues: 1451-1580; Coverage: 8%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand MRD 3 x MRD
Ligand MPD 3 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P65
Unit cell:
a: 86.783Å b: 86.783Å c: 97.959Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.228
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali et al. (2018)
1 more