› 5ei0

X-ray diffraction
2.5Å resolution

Structure of RCL-cleaved vaspin (serpinA12)

Released:
DOI: 10.2210/pdb5ei0/pdb
PDB entry 5ei0 coloured by chain, front view.
PDB entry 5ei0 coloured by chain, side view.
PDB entry 5ei0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cleaved vaspin (serpinA12).
Pippel J, Kuettner EB, Ulbricht D, Daberger J, Schultz S, Heiker JT, Sträter N
Biol Chem 397 111-23 (2016)
PMID: 26529565

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin A12 Chains: A, E
Molecule details ›
Chains: A, E
Length: 413 amino acids
Theoretical weight: 47.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IW75 (Residues: 22-414; Coverage: 100%)
Gene name: SERPINA12
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 60.392Å b: 104.422Å c: 62.965Å
α: 90° β: 96.9° γ: 90°
R-values:
R R work R free
0.227 0.224 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).
Ulbricht et al. (2017)