› 5eli

X-ray diffraction
3.1Å resolution

Triggering receptor expressed on myeloid cells 2

Released:
DOI: 10.2210/pdb5eli/pdb
PDB entry 5eli coloured by chain, front view.
PDB entry 5eli coloured by chain, side view.
PDB entry 5eli coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ
Elife 5 (2016)
PMID: 27995897

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triggering receptor expressed on myeloid cells 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZC2 (Residues: 19-133; Coverage: 54%)
Gene name: TREM2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6422
Unit cell:
a: 125.763Å b: 125.763Å c: 183.659Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.261 0.26 0.274
Expression system: Homo sapiens

Quick links

Citations

34 review citations

Microglia Function in the Central Nervous System During Health and Neurodegeneration.
Colonna et al. (2017)
33 more

10 mentions without citation

TREM2-Ligand Interactions in Health and Disease.
Kober et al. (2017)
9 more